Invention Grant
US08853171B2 1′-substituted carba-nucleoside analogs for antiviral treatment
有权
1'-取代的碳 - 核苷类似物用于抗病毒治疗
- Patent Title: 1′-substituted carba-nucleoside analogs for antiviral treatment
- Patent Title (中): 1'-取代的碳 - 核苷类似物用于抗病毒治疗
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Application No.: US13649511Application Date: 2012-10-11
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Publication No.: US08853171B2Publication Date: 2014-10-07
- Inventor: Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang
- Applicant: Gilead Sciences, Inc.
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H5/04 ; C07H7/06 ; C07H19/23 ; C07D487/04
Abstract:
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Public/Granted literature
- US20130344028A2 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT Public/Granted day:2013-12-26
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