Invention Grant
- Patent Title: Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
- Patent Title (中): 使用粪便样受体抑制剂预防和治疗高胆固醇血症和高脂血症及其相关疾病
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Application No.: US12574576Application Date: 2009-10-06
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Publication No.: US08853177B2Publication Date: 2014-10-07
- Inventor: Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
- Applicant: Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
The invention provides the use of TLR inhibitors or a pharmaceutically acceptable derivative thereof, optionally in combination with one or more lipid lowering composition, cholesterol lowering composition, diuretics, non-steroidal anti-inflammatory compounds (NSAIDs), antibodies, antisense oligonucleotides, TLR agonists, TLR antagonists, peptides, proteins or gene therapy vectors or combinations thereof for the prevention or treatment of hypercholesterolemia and/or hyperlipidemia and/or diseases associated therewith.
Public/Granted literature
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