Invention Grant
US08853179B2 Reengineering mRNA primary structure for enhanced protein production
有权
重组mRNA一级结构，增强蛋白质生产
- Patent Title: Reengineering mRNA primary structure for enhanced protein production
- Patent Title (中): 重组mRNA一级结构，增强蛋白质生产
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Application No.: US13203229Application Date: 2010-02-24
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Publication No.: US08853179B2Publication Date: 2014-10-07
- Inventor: Vincent P. Mauro , Stephen A. Chappell , Wei Zhou , Gerald M. Edelman
- Applicant: Vincent P. Mauro , Stephen A. Chappell , Wei Zhou , Gerald M. Edelman
- Applicant Address: US CA LaJolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA LaJolla
- Agency: Cooley LLP
- Agent Ivor Elrifi; Christina K. Stock
- International Application: PCT/US2010/000567 WO 20100224
- International Announcement: WO2010/098861 WO 20100902
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12P21/02
Abstract:
Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3′ UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.
Public/Granted literature
- US20120053333A1 Reengineering MRNA Primary Structure For Enhanced Protein Production Public/Granted day:2012-03-01
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