Invention Grant
US08853198B2 Agents for treating disorders involving modulation of ryanodine receptors
有权
用于治疗涉及调节兰诺定受体的疾病的药剂
- Patent Title: Agents for treating disorders involving modulation of ryanodine receptors
- Patent Title (中): 用于治疗涉及调节兰诺定受体的疾病的药剂
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Application No.: US14076474Application Date: 2013-11-11
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Publication No.: US08853198B2Publication Date: 2014-10-07
- Inventor: Jiaming Yan , Sandro Belvedere , Yael Webb , Marc Bertrand , Nicole Villeneuve
- Applicant: Les Laboratoires Servier , Armgo Pharma, Inc.
- Applicant Address: FR Suresnes Cedex US NY Tarrytown
- Assignee: Les Laboratoires Servier,ARMGO Pharma, Inc.
- Current Assignee: Les Laboratoires Servier,ARMGO Pharma, Inc.
- Current Assignee Address: FR Suresnes Cedex US NY Tarrytown
- Agency: Hueschen and Sage
- Priority: EP12167732 20120511
- Main IPC: A61K31/554
- IPC: A61K31/554 ; C07D281/10 ; A61K31/7088 ; C07D285/36
Abstract:
The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
Public/Granted literature
- US20140088171A1 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS Public/Granted day:2014-03-27
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