Invention Grant
US08853212B2 Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
有权
取代的氨基四氢硫代吡喃及其衍生物作为二肽基肽酶-IV抑制剂用于治疗糖尿病
- Patent Title: Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
- Patent Title (中): 取代的氨基四氢硫代吡喃及其衍生物作为二肽基肽酶-IV抑制剂用于治疗糖尿病
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Application No.: US13520653Application Date: 2011-02-17
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Publication No.: US08853212B2Publication Date: 2014-10-07
- Inventor: Robert R. Wilkening , James M. Apgar , Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Lan Wei
- Applicant: Robert R. Wilkening , James M. Apgar , Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Lan Wei
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp
- Current Assignee: Merck Sharp & Dohme Corp
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Anna L. Cocuzzo
- International Application: PCT/US2011/025182 WO 20110217
- International Announcement: WO2011/103256 WO 20110825
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D498/04 ; A61K31/519 ; A61K31/404 ; A61K31/4162 ; A61K31/4188 ; A61K31/424 ; A61K31/4985 ; A61P29/00 ; A61P37/00 ; A61P9/00 ; A61P3/10 ; C07D335/02
Abstract:
The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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