Invention Grant
US08853216B2 Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
有权
羟基化嘧啶环戊烷作为AKT蛋白激酶抑制剂
- Patent Title: Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
- Patent Title (中): 羟基化嘧啶环戊烷作为AKT蛋白激酶抑制剂
-
Application No.: US12811983Application Date: 2009-01-09
-
Publication No.: US08853216B2Publication Date: 2014-10-07
- Inventor: Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
- Applicant: Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
- Applicant Address: US CO Boulder US CA South San Francisco
- Assignee: Array BioPharma, Inc.,Genentech, Inc.
- Current Assignee: Array BioPharma, Inc.,Genentech, Inc.
- Current Assignee Address: US CO Boulder US CA South San Francisco
- Agency: Viksnins Harris & Padys PLLP
- International Application: PCT/US2009/030602 WO 20090109
- International Announcement: WO2009/089453 WO 20090716
- Main IPC: C07D239/70
- IPC: C07D239/70 ; A61K31/517 ; A61P35/00 ; A61P29/00 ; A61P25/00 ; A61P9/00 ; A61P15/02 ; A61P17/00
Abstract:
The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20100292244A1 HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR Public/Granted day:2010-11-18
Information query
