Invention Grant
- Patent Title: Compounds useful as inhibitors of ATR kinase
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Application No.: US13631727Application Date: 2012-09-28
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Publication No.: US08853217B2Publication Date: 2014-10-07
- Inventor: Jean-Damien Charrier , Pierre-Henri Storck , John Studley , Francoise Yvonne Theodora Marie Pierard
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Jennifer G. Che
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; A61K38/00 ; A61P35/00 ; C12P15/00 ; G01N33/53 ; A61K31/497 ; C07D413/14 ; A61K45/06

Abstract:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
Public/Granted literature
- US20130096139A1 Compounds Useful as Inhibitors of ATR Kinase Public/Granted day:2013-04-18
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