Invention Grant
US08853225B2 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazoline-6-yloxy]-1,4-diaza-spiro[5.5] undecane-5-one dimaleate, use thereof as a medicament and method for the production thereof
有权
9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基氧基] -1,4-二氮杂 - 螺[5.5]十一碳烷-5-酮二马来酸盐，其用作药物 及其制造方法
![9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazoline-6-yloxy]-1,4-diaza-spiro[5.5] undecane-5-one dimaleate, use thereof as a medicament and method for the production thereof](/docs/US/2014-10-07/US08853225B2/abs.jpg.600x600.jpg)
- Patent Title: 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazoline-6-yloxy]-1,4-diaza-spiro[5.5] undecane-5-one dimaleate, use thereof as a medicament and method for the production thereof
- Patent Title (中): 9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基氧基] -1,4-二氮杂 - 螺[5.5]十一碳烷-5-酮二马来酸盐，其用作药物 及其制造方法
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Application No.: US13359807Application Date: 2012-01-27
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Publication No.: US08853225B2Publication Date: 2014-10-07
- Inventor: Waldermar Pfrengle , Guenther Huchler , Markus Ostermeier , Peter Sieger
- Applicant: Waldermar Pfrengle , Guenther Huchler , Markus Ostermeier , Peter Sieger
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Edward S. Lazer
- Priority: EP11152895 20110201
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/517 ; C07D239/72 ; C07D401/00
![9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazoline-6-yloxy]-1,4-diaza-spiro[5.5] undecane-5-one dimaleate, use thereof as a medicament and method for the production thereof](/abs-image/US/2014/10/07/US08853225B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a compound of formula (I), which has valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, processes for stereoselectively preparing these compounds, particularly pharmaceutical formulations suitable for inhalation and their use for the treatment of diseases, particularly tumoral diseases, benign prostatic hyperplasia and diseases of the lungs and airways.
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