Invention Grant
US08853237B2 Naphthyridinone analogs as mGluR5 positive allosteric modulators
有权
萘吡酮类似物作为mGluR5阳性变构调节剂
- Patent Title: Naphthyridinone analogs as mGluR5 positive allosteric modulators
- Patent Title (中): 萘吡酮类似物作为mGluR5阳性变构调节剂
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Application No.: US13340641Application Date: 2011-12-29
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Publication No.: US08853237B2Publication Date: 2014-10-07
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones
- Applicant: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D513/02 ; C07D515/02
Abstract:
In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20120172391A1 NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2012-07-05
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