Invention Grant
US08853249B2 Method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof
有权
用于生产作为p27蛋白酶体降解的抑制剂的大环化合物的中间体的方法，例如铁蛋白及其衍生物
- Patent Title: Method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof
- Patent Title (中): 用于生产作为p27蛋白酶体降解的抑制剂的大环化合物的中间体的方法，例如铁蛋白及其衍生物
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Application No.: US13513128Application Date: 2010-12-14
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Publication No.: US08853249B2Publication Date: 2014-10-07
- Inventor: Markus Kalesse , Ulrike Eggert
- Applicant: Markus Kalesse , Ulrike Eggert
- Applicant Address: DE Braunschweig DE Hannover DE Hannover
- Assignee: Helmholtz-Zentrum für Infektionsforschungs GmbH,Medizinische Hochschule Hannover,Gottfried Wilhelm Leibniz Universität
- Current Assignee: Helmholtz-Zentrum für Infektionsforschungs GmbH,Medizinische Hochschule Hannover,Gottfried Wilhelm Leibniz Universität
- Current Assignee Address: DE Braunschweig DE Hannover DE Hannover
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/EP2010/069594 WO 20101214
- International Announcement: WO2011/073173 WO 20110623
- Main IPC: A61K31/429
- IPC: A61K31/429 ; C07D513/08 ; C07D209/20 ; C07B53/00
Abstract:
The present invention relates to an improved method for the synthesis of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof.
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