Invention Grant
US08853271B2 Method for inhibiting activity and/or expression of matrix metalloproteinase, inhibiting phosphorylation of mitogen-activated protein kinase, and/or promoting expression of collagen using tormentic acid
有权
用于抑制基质金属蛋白酶的活性和/或表达，抑制丝裂原活化蛋白激酶的磷酸化和/或促进胶原蛋白的表达的方法
- Patent Title: Method for inhibiting activity and/or expression of matrix metalloproteinase, inhibiting phosphorylation of mitogen-activated protein kinase, and/or promoting expression of collagen using tormentic acid
- Patent Title (中): 用于抑制基质金属蛋白酶的活性和/或表达，抑制丝裂原活化蛋白激酶的磷酸化和/或促进胶原蛋白的表达的方法
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Application No.: US12955336Application Date: 2010-11-29
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Publication No.: US08853271B2Publication Date: 2014-10-07
- Inventor: Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
- Applicant: Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
- Applicant Address: TW Taichung
- Assignee: China Medical University
- Current Assignee: China Medical University
- Current Assignee Address: TW Taichung
- Agency: Greer, Burns & Crain, Ltd.
- Priority: TW99129879A 20100903
- Main IPC: A61K31/191
- IPC: A61K31/191 ; A61P17/00 ; A61Q19/08 ; A61K8/365 ; C07C61/29 ; A61K31/19 ; A61K8/63
Abstract:
A method for inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and/or promoting the expression of collagen in a mammal is provided. The method comprises administrating to the mammal an effective amount of an active component selected from a group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound, and combinations thereof:
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