Invention Grant
- Patent Title: Membrane type-1 matrix metalloprotein inhibitors and uses thereof
- Patent Title (中): 膜1型基质金属蛋白酶抑制剂及其用途
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Application No.: US13139931Application Date: 2009-12-17
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Publication No.: US08853353B2Publication Date: 2014-10-07
- Inventor: Richard Beliveau , Denis Gingras , Carine Nyalendo
- Applicant: Richard Beliveau , Denis Gingras , Carine Nyalendo
- Applicant Address: CA Montreal
- Assignee: Angiochem, Inc.
- Current Assignee: Angiochem, Inc.
- Current Assignee Address: CA Montreal
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- International Application: PCT/CA2009/001858 WO 20091217
- International Announcement: WO2010/069074 WO 20100624
- Main IPC: A61K38/55
- IPC: A61K38/55 ; C07K4/00 ; C12N9/64 ; A61K38/48
Abstract:
Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.
Public/Granted literature
- US20110305750A1 MEMBRANE TYPE-1 MATRIX METALLOPROTEIN INHIBITORS AND USES THEREOF Public/Granted day:2011-12-15
Information query
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