Invention Grant
US08853360B2 Engineered botulinum neurotoxin C1 with selective substrate specificity
有权
具有选择性底物特异性的工程肉毒杆菌神经毒素C1
- Patent Title: Engineered botulinum neurotoxin C1 with selective substrate specificity
- Patent Title (中): 具有选择性底物特异性的工程肉毒杆菌神经毒素C1
-
Application No.: US13167156Application Date: 2011-06-23
-
Publication No.: US08853360B2Publication Date: 2014-10-07
- Inventor: Meyer B. Jackson , Dongsheng Wang
- Applicant: Meyer B. Jackson , Dongsheng Wang
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00 ; C12Q1/02 ; A61K39/08 ; C07H21/04 ; C07K14/33
Abstract:
An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
Public/Granted literature
- US20110318385A1 ENGINEERED BOTULINUM NEUROTOXIN C1 WITH SELECTIVE SUBSTRATE SPECIFICITY Public/Granted day:2011-12-29
Information query
