Invention Grant
US08853364B2 Prostate stem cell antigen (PSCA) variants and subsequences thereof
有权
前列腺干细胞抗原（PSCA）变体及其子序列
- Patent Title: Prostate stem cell antigen (PSCA) variants and subsequences thereof
- Patent Title (中): 前列腺干细胞抗原（PSCA）变体及其子序列
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Application No.: US12561832Application Date: 2009-09-17
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Publication No.: US08853364B2Publication Date: 2014-10-07
- Inventor: Wangmao Ge , Pia M. Challita-Eid , Arthur B. Raitano , Aya Jakobovits
- Applicant: Wangmao Ge , Pia M. Challita-Eid , Arthur B. Raitano , Aya Jakobovits
- Applicant Address: US CA Santa Monica
- Assignee: Agensys, Inc.
- Current Assignee: Agensys, Inc.
- Current Assignee Address: US CA Santa Monica
- Agency: Morrison & Foerster LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; A61K39/00 ; A61K51/10 ; C07K16/30 ; C07K14/705 ; G01N33/574 ; C07K14/47 ; G01N33/566
Abstract:
PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
Public/Granted literature
- US20100055120A1 PROSTATE STEM CELL ANTIGEN (PSCA) VARIANTS AND SUBSEQUENCES THEREOF Public/Granted day:2010-03-04
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