Invention Grant
- Patent Title: Toll like receptor modulators
- Patent Title (中): Toll样受体调节剂
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Application No.: US12192432Application Date: 2008-08-15
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Publication No.: US08853375B2Publication Date: 2014-10-07
- Inventor: Ekambar Kandimalla , Lakshmi Bhagat , Mallikarjuna Putta , Daqing Wang , Sudhir Agrawal
- Applicant: Ekambar Kandimalla , Lakshmi Bhagat , Mallikarjuna Putta , Daqing Wang , Sudhir Agrawal
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04
Abstract:
The invention relates to TLR9 antagonist compounds and their therapeutic or prophylactic use. The invention provides novel immune regulatory oligonucleotides and immunomers as antagonist of TLRs and methods of use thereof. These immune regulatory oligonucleotides have unique sequences that suppress, without completely ablating, TLR-mediated signaling in response to a TLR ligand or TLR signaling agonist. The methods may have use in the prevention and treatment of autoimmunity, inflammation, inflammatory bowel disease, lupus, allergy, asthma, infection, sepsis, cancer and immunodeficiency.
Public/Granted literature
- US20090053148A1 TOLL LIKE RECEPTOR MODULATORS Public/Granted day:2009-02-26
Information query
