Invention Grant
US08853402B2 Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation
有权
通过氢化将吗啡喃生物碱的6-酮基还原成6-羟基的方法
- Patent Title: Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation
- Patent Title (中): 通过氢化将吗啡喃生物碱的6-酮基还原成6-羟基的方法
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Application No.: US13390818Application Date: 2010-08-13
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Publication No.: US08853402B2Publication Date: 2014-10-07
- Inventor: George Scott Wilson , Maureen Joan Young
- Applicant: George Scott Wilson , Maureen Joan Young
- Applicant Address: GB London
- Assignee: Johnson Matthey Public Limited Company
- Current Assignee: Johnson Matthey Public Limited Company
- Current Assignee Address: GB London
- Agency: RatnerPrestia
- Priority: GB0914338.9 20090817
- International Application: PCT/GB2010/051343 WO 20100813
- International Announcement: WO2011/021029 WO 20110224
- Main IPC: C07D489/08
- IPC: C07D489/08 ; C07D489/02
Abstract:
A process for the reduction of a 6-keto group in a morphinan alkaloid to the corresponding 6-hydroxy group includes hydrogenating the 6-keto group using gaseous hydrogen in the presence of a heterogeneous catalyst and a solvent, to yield the 6-hydroxy morphinan alkaloid, wherein the reduction is carried out at a pH in the range of about 5 to about 7, and the 6-hydroxy morphinan alkaloid has an α:β ratio of >85:15.
Public/Granted literature
- US20120209002A1 PROCESS FOR REDUCING THE 6-KETO GROUP OF A MORPHINAN ALKALOID TO THE 6-HYDROXY GROUP BY HYDROGENATION Public/Granted day:2012-08-16
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