Invention Grant
US08853406B2 Substituted phenylenediamines as inhibitors of the interaction between MDM2 and P53
有权
取代的苯二胺作为MDM2和P53相互作用的抑制剂
- Patent Title: Substituted phenylenediamines as inhibitors of the interaction between MDM2 and P53
- Patent Title (中): 取代的苯二胺作为MDM2和P53相互作用的抑制剂
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Application No.: US12672381Application Date: 2008-08-05
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Publication No.: US08853406B2Publication Date: 2014-10-07
- Inventor: Alain Philippe Poncelet , Bruno Schoentjes , Pierre-Henri Storck , Virginie Sophie Poncelet , Carina Leys
- Applicant: Alain Philippe Poncelet , Bruno Schoentjes , Pierre-Henri Storck , Virginie Sophie Poncelet , Carina Leys
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP07113878 20070806
- International Application: PCT/EP2008/060291 WO 20080805
- International Announcement: WO2009/019274 WO 20090212
- Main IPC: C07D221/04
- IPC: C07D221/04 ; A61K31/435 ; C07D401/12
Abstract:
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I).
Public/Granted literature
- US20110130418A1 SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 Public/Granted day:2011-06-02
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