Invention Grant
- Patent Title: Cyclopropylamines as LSD1 inhibitors
- Patent Title (中): 环丙胺作为LSD1抑制剂
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Application No.: US14007035Application Date: 2012-03-26
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Publication No.: US08853408B2Publication Date: 2014-10-07
- Inventor: Neil W. Johnson , Jiri Kasparec
- Applicant: Neil W. Johnson , Jiri Kasparec
- Applicant Address: GB Brentford, Middlesex
- Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
- Current Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Duke M. Fitch; John Lemanowicz; William Majarian
- International Application: PCT/US2012/030552 WO 20120326
- International Announcement: WO2012/135113 WO 20121004
- Main IPC: C07D211/32
- IPC: C07D211/32 ; A01N43/40 ; A61K31/445 ; C07D401/04 ; C07D223/04 ; C07D265/30 ; C07D211/96 ; C07C271/24 ; C07D413/06 ; C07D211/26 ; C07D401/06 ; C07D401/10 ; C07C211/35 ; C07D211/62 ; C07F9/59 ; C07D207/09 ; C07F5/02 ; C07C211/36
Abstract:
This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.
Public/Granted literature
- US20140018393A1 CYCLOPROPYLAMINES AS LSD1 INHIBITORS Public/Granted day:2014-01-16
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