Invention Grant
- Patent Title: Protein cross-linking inhibitor
- Patent Title (中): 蛋白质交联抑制剂
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Application No.: US13058647Application Date: 2009-08-11
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Publication No.: US08853424B2Publication Date: 2014-10-07
- Inventor: Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
- Applicant: Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
- Applicant Address: JP Kawaguchi-Shi
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP Kawaguchi-Shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2008-207315 20080811
- International Application: PCT/JP2009/064206 WO 20090811
- International Announcement: WO2010/018837 WO 20100218
- Main IPC: C07D333/00
- IPC: C07D333/00 ; A61K31/67 ; C07F5/02 ; A61K31/69
Abstract:
The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (1) R3—[—X—B(ZR1)—Y—]n—R4, (2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4, (3) R3—[—X—B(ZR1)—]n—R4, (4) R3—[—B(ZR2)—W—]n—R4, (5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2, (6) R3—B(OH)2, (7) R3—B(ZR1)—X—B(ZR2)—R4, (8) R3—B(R1)—O—B(R2)—R4, (9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4, (10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4, (11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (12) [R3—X—B(ZR1)—Y]2B(ZR2), (13) wherein each symbol is as defined in the DESCRIPTION.
Public/Granted literature
- US20110212919A1 PROTEIN CROSS-LINKING INHIBITOR Public/Granted day:2011-09-01
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