Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
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Application No.: US13908619Application Date: 2013-06-03
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Publication No.: US08853427B2Publication Date: 2014-10-07
- Inventor: Melissa Fleury , Roland Gendron , Adam D. Hughes
- Applicant: Melissa Fleury , Roland Gendron , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: C07C229/34
- IPC: C07C229/34 ; C07C271/22 ; C07D231/14 ; C07D231/18 ; C07D233/70 ; C07D235/08 ; C07D237/14 ; C07D239/34 ; C07D249/04 ; C07D249/10 ; C07D249/12 ; C07D249/18 ; C07D261/12 ; C07D263/18 ; C07D309/40 ; C07D401/04 ; C07D405/12 ; C07D471/04 ; C07D319/06
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20130261316A1 NEPRILYSIN INHIBITORS Public/Granted day:2013-10-03
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