An imager may include analog-to-digital converter circuitry that converts an analog input voltage to a digital output value by generating a number of samples of the analog input voltage. The analog input voltage may be formed from the difference between a pixel signal and a reference signal received at first and second inputs of the analog-to-digital converter circuitry. Processing circuitry may control the number of samples generated from the analog input voltage based on a desired gain level. The analog-to-digital converter circuitry may include a counter that counts to a maximum value. Ramp generation circuitry may generate a ramp signal based on the counter value and apply the ramp signal to the pixel signal at the first input of the analog-to-digital converter circuitry. The total time for generating samples for each different desired gain level may be constant while generating the ramp signal with a slope having a constant magnitude.