A method of driving an electrophoretic display device displays an image during an image frame divided into a plurality of sub-frames. Sub-frame periods of the plurality of sub-frames are determined based on a predetermined resolution of the image. The plurality of sub-frames have sub-frame periods that differ from one another. A plurality of unit pixels are initialized by applying a common voltage to a common electrode and by applying a first voltage to a plurality of pixel electrodes. Each pixel electrode corresponds to a respective one of the plurality of unit pixels. Gray levels of the plurality of unit pixels are controlled by selectively applying one of the common voltage and a second voltage to each pixel electrode during each sub-frame.