A network endpoint system and related method and computer program product for use in a network to support enhanced end-to-end QoS in the network. The network endpoint system is adapted to receive network data of varying priority on behalf of a data consumer operating at the application layer of a network protocol stack implemented by the network endpoint system. The network endpoint system includes a network interface controller adapted to receive network frames containing the network data, plural network data handling channels each having an associated priority, and priority processing logic adapted to transfer the network data from the network interface controller to the plural data handling channels on a prioritized basis according to the network data priority. Also disclosed are a network interface controller and a network node to support enhanced end-to-end QoS in a network.