Circuits and methods are disclosed for reducing interference from transmitter leakage in a radio transceiver. An exemplary method for reducing interference from transmitter leakage in a radio transceiver comprises downconverting, filtering, and sampling a radio frequency signal comprising a desired signal and a transmitter leakage signal to obtain a sampled signal of interest. The method further comprises generating a sampled distortion signal estimate that estimates one or more distortion products of the transmitter leakage signal, such as a squared amplitude obtained from a square-law device or corresponding digital function. Finally, the method comprises combining the sampled distortion signal estimate with the sampled signal of interest to obtain interference-reduced signal samples. In some embodiments, this may comprise correlating the sampled distortion signal estimate with the sampled signal of interest to determine a scaling factor, scaling the sampled distortion signal estimate with the scaling factor, and subtracting the scaled distortion signal estimate from the sampled signal of interest to obtain the interference-reduced signal samples.