A data processing device includes a cache having a plurality of cache lines. Each cache line has a lockout state that indicates whether an error has been detected for data accessed at the cache line. The lockout state of a cache line is indicated by a set of one or more lockout bits associate with the cache line. When a cache line is in a locked-out state, the cache line is not used by the cache. Accordingly, a locked-out cache line is not employed by the cache to satisfy a cache accesses, and is not used to store data retrieved from memory in response to a cache miss. In response to determining the detected error likely did not result from a hardware failure or other persistent condition, memory error management software can reset the lockout state of the cache line.