发明授权
- 专利标题: Adjuvant comprising aluminum, oligonucleotide and polycation
- 专利标题(中): 佐剂包括铝,寡核苷酸和聚阳离子
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申请号: US12870708申请日: 2010-08-27
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公开(公告)号: US08858958B2公开(公告)日: 2014-10-14
- 发明人: Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
- 申请人: Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 代理商 Helen Lee; Otis Littlefield
- 主分类号: A61K39/095
- IPC分类号: A61K39/095 ; A61K39/39 ; A61K39/00 ; A61K39/108 ; A61K39/085 ; A61K39/09 ; A61K39/155
摘要:
An immunological adjuvant comprises an aluminum salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be included in a composition with an immunogen e.g. to elicit an immune response that protects against a bacterial disease or a fungal disease.
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