Invention Grant
US08859587B2 (2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof
有权
（2E）-3-苯基-N- [2,2,2-三氟-1 - [[8-喹啉氨基]硫代甲基]氨基]乙基] -2-丙烯酰胺及其药物用途
![(2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof](/docs/US/2014-10-14/US08859587B2/abs.jpg.600x600.jpg)
- Patent Title: (2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof
- Patent Title (中): （2E）-3-苯基-N- [2,2,2-三氟-1 - [[8-喹啉氨基]硫代甲基]氨基]乙基] -2-丙烯酰胺及其药物用途
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Application No.: US13697808Application Date: 2010-05-14
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Publication No.: US08859587B2Publication Date: 2014-10-14
- Inventor: Kunlun He , Song Li , Lili Wang , Xin Li , Wu Zhong , Guoliang Hu , Jie Wang , Ruijin Li , Chunlei Liu , Junhai Xiao , Long Long , Wei Li , Hua Chen
- Applicant: Kunlun He , Song Li , Lili Wang , Xin Li , Wu Zhong , Guoliang Hu , Jie Wang , Ruijin Li , Chunlei Liu , Junhai Xiao , Long Long , Wei Li , Hua Chen
- Applicant Address: CN Beijing
- Assignee: Chinese PLA General Hospital
- Current Assignee: Chinese PLA General Hospital
- Current Assignee Address: CN Beijing
- Agency: Howard & Howard Attorneys PLLC
- International Application: PCT/CN2010/000688 WO 20100514
- International Announcement: WO2011/140682 WO 20111117
- Main IPC: A61K31/04
- IPC: A61K31/04 ; C07D215/40 ; A61K31/47
![(2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof](/abs-image/US/2014/10/14/US08859587B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.
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