A drumstick weight adjustment structure includes a plastic stick holder and at least one weight block. The plastic stick holder has at least one hole. The weight block can be inserted into the hole and tightly held therein, and also can be removed therefrom. Users can adjust the number of the weight block held in the hole according to requirements to change the weight of the plastic stick holder, thereby change the force of the plastic stick holder striking a drum to generate desired timbre to meet use requirements.