The disclosure is directed to techniques for encoder-assisted adaptive interpolation of video frames. According to the disclosed techniques, an encoder generates information to assist a decoder in interpolation of a skipped video frame, i.e., an S frame. The information permits the decoder to reduce visual artifacts in the interpolated frame and thereby achieve improved visual quality. The information may include interpolation equation labels that identify selected interpolation equations to be used by the decoder for individual video blocks. As an option, to conserve bandwidth, the equation labels may be transmitted for only selected video blocks that meet a criterion for encoder-assisted interpolation. Other video blocks without equation labels may be interpolated according to a default interpolation technique.