Disposable plastic bags are provided that include multiple internal compartments and methods for making such bags. In one embodiment, a disposable plastic bag includes substantially transparent outer panels attached together to define a main compartment, an opening for accessing the main compartment, a main closure for selectively opening and closing the opening into the main compartment; and a plurality of internal panels attached to one of the outer panels to define a plurality of internal compartments separate from and accessible through the main compartment, the internal panels comprising closures for selectively opening and closing the respective internal compartments.