发明授权
US08877453B2 Diagnosing and managing venous thromboembolism and intracardiac thrombi using a provoked D-dimer test
有权
使用诱发的D-二聚体测试诊断和管理静脉血栓栓塞和心内血栓
- 专利标题： Diagnosing and managing venous thromboembolism and intracardiac thrombi using a provoked D-dimer test
- 专利标题（中）： 使用诱发的D-二聚体测试诊断和管理静脉血栓栓塞和心内血栓
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申请号： US13400818申请日： 2012-02-21
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公开(公告)号： US08877453B2公开(公告)日： 2014-11-04
- 发明人: Vincent J. B. Robinson
- 申请人： Vincent J. B. Robinson
- 申请人地址： US GA Augusta
- 专利权人： Georgia Regents Research Institute, Inc.
- 当前专利权人： Georgia Regents Research Institute, Inc.
- 当前专利权人地址： US GA Augusta
- 代理机构： Pabst Patent Group LLP
- 主分类号： G01N33/86
- IPC分类号： G01N33/86 ; G01N33/68
摘要：
The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention comprises the steps of: obtaining a plasma sample from said individual; determining the baseline level of D-dimer in said sample; contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin; and measuring the level of D-dimer is said sample after administering or contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin, wherein a significantly greater concentration of D-dimer after contact with a compound that catalyzes the conversion of plasminogen into plasmin than prior to contact with a compound that catalyzes the conversion of plasminogen into plasmin indicates that said individual has pulmonary embolism or venous thromboembolism.
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