发明授权
- 专利标题： Combination, kit and method of reducing intraocular pressure
- 专利标题（中）： 降低眼内压的组合，试剂盒和方法
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申请号： US13004380申请日： 2011-01-11
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公开(公告)号： US08877732B2公开(公告)日： 2014-11-04
- 发明人: Norman N. Kim , William K. McVicar , Thomas G. McCauley , Rudolf A. Baumgartner
- 申请人： Norman N. Kim , William K. McVicar , Thomas G. McCauley , Rudolf A. Baumgartner
- 申请人地址： US MA Lexington
- 专利权人： Inotek Pharmaceuticals Corporation
- 当前专利权人： Inotek Pharmaceuticals Corporation
- 当前专利权人地址： US MA Lexington
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Cynthia L. Kanik
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/24 ; A61K31/215 ; A61K31/235 ; A01N43/04 ; A01N37/08 ; A01N37/10 ; A61K9/00 ; A61K45/06 ; A61K31/7076 ; A61K31/19 ; A61K31/165 ; A61K31/216 ; A01N37/12 ; A01N37/44
摘要：
The present invention is directed to a combination or a kit comprising a prostaglandin analog and an adenosine receptor A1 agonist and to a method of reducing intraocular pressure (IOP) in a subject using such combination or kit. In one embodiment, the prostaglandin analog is latanoprost and the adenosine receptor A1 agonist is Compound A, ((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate, having the structure,
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