发明授权
US08877749B2 Spirocyclic compounds as modulators of chemokine receptor activity
有权
螺环化合物作为趋化因子受体活性的调节剂
- 专利标题： Spirocyclic compounds as modulators of chemokine receptor activity
- 专利标题（中）： 螺环化合物作为趋化因子受体活性的调节剂
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申请号： US13500323申请日： 2010-10-06
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公开(公告)号： US08877749B2公开(公告)日： 2014-11-04
- 发明人: T. G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
- 申请人： T. G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibbs Company
- 当前专利权人： Bristol-Myers Squibbs Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Hong Liu
- 国际申请： PCT/US2010/051577 WO 20101006
- 国际公布： WO2011/044197 WO 20110414
- 主分类号： A61K31/535
- IPC分类号： A61K31/535 ; C07D413/12 ; C07D471/04 ; C07D405/12 ; A61K31/4427 ; C07D401/12
摘要：
The present application describes modulators of chemokine receptor activity of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
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