发明授权
- 专利标题： Inorganic salt complexes of vildagliptin
- 专利标题（中）： 维格列汀的无机盐配合物
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申请号： US13500356申请日： 2010-10-07
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公开(公告)号： US08877799B2公开(公告)日： 2014-11-04
- 发明人: Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
- 申请人： Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
- 申请人地址： HU Budapest
- 专利权人： Egis Gyogyszergynar Nyilvanosan Muekoedoe Reszvenytarsasag
- 当前专利权人： Egis Gyogyszergynar Nyilvanosan Muekoedoe Reszvenytarsasag
- 当前专利权人地址： HU Budapest
- 代理机构： Lucas & Mercanti, LLP
- 代理商 Jonathan Myers
- 优先权： HU0900638 20091007
- 国际申请： PCT/HU2010/000106 WO 20101007
- 国际公布： WO2011/042765 WO 20110414
- 主分类号： C07D207/16
- IPC分类号： C07D207/16
摘要：
The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.
公开/授权文献
- US20130005790A1 INORGANIC SALT COMPLEXES OF VILDAGLIPTIN 公开/授权日：2013-01-03
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