发明授权
- 专利标题： Single-chain insulin
- 专利标题（中）： 单链胰岛素
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申请号： US12251901申请日： 2008-10-15
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公开(公告)号： US08883449B2公开(公告)日： 2014-11-11
- 发明人: Thomas Børglum Kjeldsen , Morten Schlein , Anders Robert Sørensen , Peter Madsen
- 申请人： Thomas Børglum Kjeldsen , Morten Schlein , Anders Robert Sørensen , Peter Madsen
- 申请人地址： DK Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Bagsvaerd
- 代理商 Jianjie Hu
- 优先权： DK200301786 20031203
- 主分类号： C07K14/62
- IPC分类号： C07K14/62 ; A61K36/28 ; C12N5/10 ; C12N1/21 ; C12N15/17 ; C12N15/63 ; A61K38/00
摘要：
The present invention is related to single-chain insulin having insulin activity comprising a B- and an A-chain or a modified B- and A-chain connected by a connecting peptide of from 6-11 amino acids. The single-chain insulins will have biological insulin activity and an IGF-1 receptor affinity similar to or lower than that of human insulin and a high physical stability. The single-chain insulin may contain at least one basic amino acid residues in the connecting peptide. The single-chain insulins may also be acylated in one or more Lys residues.
公开/授权文献
- US20090170750A1 Single-Chain Insulin 公开/授权日：2009-07-02
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