发明授权
- 专利标题： Modulation of diacylglycerol acyltransferase 2 expression
- 专利标题（中）： 二酰基甘油酰基转移酶2表达的调控
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申请号： US13566674申请日： 2012-08-03
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公开(公告)号： US08883997B2公开(公告)日： 2014-11-11
- 发明人: Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
- 申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Knobbe Martens LLC
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/113 ; C07H21/02
摘要：
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
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