发明授权
- 专利标题: Method of managing or treating pain
- 专利标题(中): 治疗或治疗疼痛的方法
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申请号: US13541314申请日: 2012-07-03
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公开(公告)号: US08889176B2公开(公告)日: 2014-11-18
- 发明人: Peter James Watts , Jonathan David Castile , William Columbus Lafferty , Alan Smith
- 申请人: Peter James Watts , Jonathan David Castile , William Columbus Lafferty , Alan Smith
- 申请人地址: US CA Newark
- 专利权人: Depomed, Inc.
- 当前专利权人: Depomed, Inc.
- 当前专利权人地址: US CA Newark
- 代理机构: McDermott Will & Emery LLP
- 优先权: GB0300531.1 20030110
- 主分类号: A61F13/00
- IPC分类号: A61F13/00 ; A61K31/445 ; A01N43/40 ; A01N43/16 ; A61K31/35
摘要:
A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
公开/授权文献
- US20120277267A1 METHOD OF MANAGING OR TREATING PAIN 公开/授权日:2012-11-01
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