发明授权
US08889383B2 Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
有权
使用编码具有硫解酶，HMG-CoA合成酶和HMG-CoA还原酶酶活性的多肽的基因生产甲羟戊酸，异戊二烯和类异戊二烯
- 专利标题： Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
- 专利标题（中）： 使用编码具有硫解酶，HMG-CoA合成酶和HMG-CoA还原酶酶活性的多肽的基因生产甲羟戊酸，异戊二烯和类异戊二烯
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申请号： US13459033申请日： 2012-04-27
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公开(公告)号： US08889383B2公开(公告)日： 2014-11-18
- 发明人: Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
- 申请人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
- 申请人地址： US CA Palo Alto US OH Akron
- 专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人地址： US CA Palo Alto US OH Akron
- 代理机构： Morrison & Foerster LLP
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12N1/19 ; C12P7/02 ; C12P5/00 ; C12N9/04 ; C12N9/10 ; C12P7/04 ; C12P7/42
摘要：
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
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