发明授权
US08889702B2 Derivatives of azaspiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof
有权
5-元杂环化合物的氮杂螺环烷基 - 氨基甲酸铵的衍生物,其制备及其治疗用途
- 专利标题: Derivatives of azaspiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof
- 专利标题(中): 5-元杂环化合物的氮杂螺环烷基 - 氨基甲酸铵的衍生物,其制备及其治疗用途
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申请号: US13145926申请日: 2010-02-04
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公开(公告)号: US08889702B2公开(公告)日: 2014-11-18
- 发明人: Ahmed Abouabdellah , Nathalie Chereze , Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
- 申请人: Ahmed Abouabdellah , Nathalie Chereze , Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
- 申请人地址: FR Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FR Paris
- 代理机构: Scully, Scott, Murphy & Presser P.C.
- 优先权: FR0900493 20090205
- 国际申请: PCT/FR2010/050183 WO 20100204
- 国际公布: WO2010/089510 WO 20100812
- 主分类号: A61K31/4704
- IPC分类号: A61K31/4704 ; A61K31/4427 ; C07D413/14 ; C07D417/14
摘要:
The invention relates to a compound of the general formula (I) in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, NR8R9 group; m, n, o and p are independently an integer equal to 0, 1, 2 or 3; A is a covalent bond or a C1-8-alkylene group; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl group or a trifluoromethyl group; R4 is an optionally substituted 5-member heterocyclic compound; the compound being in the form of a base or acid addition salt. The invention also relates to the therapeutic use thereof.
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