According to one embodiment, a medical image diagnosis apparatus includes a volume rendering image generation part, mask image-storage, real time fluoroscopic image generation part, subtraction image generation part, coil image generation part, and image composition part. The volume rendering image generation part generates, from volume data, a volume rendering image representing blood vessel information. The mask image-storage stores fluoroscopic mask images. The real time fluoroscopic image generation part acquires real time fluoroscopic images for each chronological sequence accompanying device insertion. The subtraction image generation part generates a subtraction image by subtraction processing on the fluoroscopic mask image stored in the mask image storage and the real time fluoroscopic image acquired for each chronological sequence. The coil image generation part generates a coil image from the fluoroscopic mask image. The image composition part generates a composite image of the volume rendering image, the subtraction image, and the coil image.