A handheld test strip illumination device includes a housing. A strip connector positioned within the housing receives a first portion of a test strip in a test strip test position. A light source is positioned within the housing. A lens/light reflecting device is aligned to receive photons emitted from the light source and direct the photons onto the first portion of the test strip within the strip connector. The first portion of the test strip within the strip connector includes a longitudinal transparent layer receiving the photons emitted from the lens/light reflecting device within the housing. The photons pass through the longitudinal transparent layer and are emitted from the longitudinal transparent layer in a second portion of the test strip positioned outside of the housing, thereby illuminating a dose area of the test strip.