发明授权
- 专利标题： Methods for inhibiting the binding of endosialin to ligands
- 专利标题（中）： 抑制内皮素与配体结合的方法
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申请号： US12873667申请日： 2010-09-01
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公开(公告)号： US08895000B2公开(公告)日： 2014-11-25
- 发明人: Yuhong Zhou , Brian Tomkowicz , Luigi Grasso , Nicholas C. Nicolaides , Philip M. Sass
- 申请人： Yuhong Zhou , Brian Tomkowicz , Luigi Grasso , Nicholas C. Nicolaides , Philip M. Sass
- 申请人地址： US PA Exton
- 专利权人： Morphotek, Inc.
- 当前专利权人： Morphotek, Inc.
- 当前专利权人地址： US PA Exton
- 代理机构： Baker & Hostetler LLP
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C07K16/28
摘要：
The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.
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