发明授权
US08895508B2 Methods for corneal endothelial proliferation using bFGF sustained-release gelatin hydrogel particles
有权
使用bFGF缓释明胶水凝胶颗粒进行角膜内皮增殖的方法
- 专利标题： Methods for corneal endothelial proliferation using bFGF sustained-release gelatin hydrogel particles
- 专利标题（中）： 使用bFGF缓释明胶水凝胶颗粒进行角膜内皮增殖的方法
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申请号： US13386844申请日： 2009-07-24
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公开(公告)号： US08895508B2公开(公告)日： 2014-11-25
- 发明人: Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
- 申请人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
- 申请人地址： JP Uji JP Osaka
- 专利权人： Yasuhiki Tabata,Senju Pharmaceutical Co., Ltd.
- 当前专利权人： Yasuhiki Tabata,Senju Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Uji JP Osaka
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 国际申请： PCT/JP2009/063624 WO 20090724
- 国际公布： WO2011/010399 WO 20110127
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; A61K9/00 ; A61K9/06 ; A61K47/42
摘要：
The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.
公开/授权文献
- US20120190621A1 CORNEAL ENDOTHELIAL CELL PROLIFERATION PROMOTER 公开/授权日：2012-07-26