发明授权
US08895695B2 Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
有权
模板固定β-发夹肽模拟物与CXCR4拮抗活性
- 专利标题： Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
- 专利标题（中）： 模板固定β-发夹肽模拟物与CXCR4拮抗活性
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申请号： US12828998申请日： 2010-07-01
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公开(公告)号： US08895695B2公开(公告)日： 2014-11-25
- 发明人: Jürg Zumbrunn , Steven J. Demarco , Sergio Lociuro , Jan Wim Vrijbloed , Frank Gombert , Reshmi Mukherjee , Kerstin Moehle , Daniel Obrecht , John Anthony Robinson , Heiko Henze , Barbara Romagnoli , Christian Ludin
- 申请人： Jürg Zumbrunn , Steven J. Demarco , Sergio Lociuro , Jan Wim Vrijbloed , Frank Gombert , Reshmi Mukherjee , Kerstin Moehle , Daniel Obrecht , John Anthony Robinson , Heiko Henze , Barbara Romagnoli , Christian Ludin
- 申请人地址： CH Allschwil CH Zürich
- 专利权人： Polyphor Ltd.,Universität Zürich
- 当前专利权人： Polyphor Ltd.,Universität Zürich
- 当前专利权人地址： CH Allschwil CH Zürich
- 代理机构： Hoffmann & Baron, LLP
- 优先权： WOPCT/EP03/04640 20030502
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C07K7/50
摘要：
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.