发明授权
US08895776B2 Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
有权
前列环素(PGI2)受体的调节剂可用于治疗与之相关的疾病
- 专利标题: Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
- 专利标题(中): 前列环素(PGI2)受体的调节剂可用于治疗与之相关的疾病
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申请号: US12933196申请日: 2009-03-17
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公开(公告)号: US08895776B2公开(公告)日: 2014-11-25
- 发明人: Thuy-Anh Tran , Weichao Chen , Bryan A. Kramer , Abu J. M. Sadeque , Anna Shifrina , Young-Jun Shin , Pureza Vallar , Ning Zou
- 申请人: Thuy-Anh Tran , Weichao Chen , Bryan A. Kramer , Abu J. M. Sadeque , Anna Shifrina , Young-Jun Shin , Pureza Vallar , Ning Zou
- 申请人地址: US CA San Diego
- 专利权人: Arena Pharmaceuticals, Inc.
- 当前专利权人: Arena Pharmaceuticals, Inc.
- 当前专利权人地址: US CA San Diego
- 国际申请: PCT/US2009/001688 WO 20090317
- 国际公布: WO2009/117095 WO 20090924
- 主分类号: C07C241/00
- IPC分类号: C07C241/00 ; C07C271/12 ; C07D213/75 ; C07D241/20 ; C07D277/48 ; C07C275/24 ; C07C275/34 ; C07C271/28 ; C07C309/15 ; C07C275/28 ; C07C275/30 ; C07D333/36
摘要:
The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).