A radio frequency transmitting system which includes first and second amplifiers, a power detector, and a calibration module. The first amplifier amplifies an input signal to generate an amplified signal in accordance with a programmable gain. The second amplifier transmits an output signal based on the amplified signal. The output signal is transmitted at a particular power by the second amplifier. The power detector measures the particular power at which the output signal is transmitted by the second amplifier. The calibration module adjusts the programmable gain of the first amplifier by a calibration offset so that the particular power measurement matches a predetermined power. The calibration module includes offset generation modules that each generate a respective calibration offset candidate based on the particular power measurement. The calibration module also includes a selection module that selects, based on the predetermined power, one of the calibration offset candidates as the calibration offset.