发明授权
US08901141B2 Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them
有权
具有促肾上腺皮质激素释放因子拮抗活性的三环化合物和含有它们的药物组合物
- 专利标题： Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them
- 专利标题（中）： 具有促肾上腺皮质激素释放因子拮抗活性的三环化合物和含有它们的药物组合物
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申请号： US12863851申请日： 2009-01-21
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公开(公告)号： US08901141B2公开(公告)日： 2014-12-02
- 发明人: Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki
- 申请人： Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki
- 申请人地址： JP Osaka
- 专利权人： Takeda Pharmaceutical Company, Limited
- 当前专利权人： Takeda Pharmaceutical Company, Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Wenderoth, Lind & Ponack, LLP
- 国际申请： PCT/JP2009/051299 WO 20090121
- 国际公布： WO2009/093747 WO 20090730
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; C07D239/70 ; C07D498/04 ; C07D487/04
摘要：
There is provided a compound of the formula (I′): wherein X is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted hydrocarbon group, etc., ring A is 5- to -8-membered heterocyclic ring, etc., and each of Y1, Y2 and Y3 is an optionally substituted carbon or a nitrogen, etc.; or ‘a salt thereof or a prodrug thereof, which have CRF receptor antagonistic activity and use thereof.