发明授权
- 专利标题： Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
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申请号： US13067838申请日： 2011-06-29
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公开(公告)号： US08901303B2公开(公告)日： 2014-12-02
- 发明人: Takuji Bando , Satoshi Aoki , Junichi Kawasaki , Makoto Ishigami , Youichi Taniguchi , Tsuyoshi Yabuuchi , Kiyoshi Fujimoto , Yoshihiro Nishioka , Noriyuki Kobayashi , Tsutomu Fujimura , Masanori Takahashi , Kaoru Abe , Tomonori Nakagawa , Koichi Shinhama , Naoto Utsumi , Michiaki Tominaga , Yoshihiro Ooi , Shohei Yamada , Kenji Tomikawa
- 申请人： Takuji Bando , Satoshi Aoki , Junichi Kawasaki , Makoto Ishigami , Youichi Taniguchi , Tsuyoshi Yabuuchi , Kiyoshi Fujimoto , Yoshihiro Nishioka , Noriyuki Kobayashi , Tsutomu Fujimura , Masanori Takahashi , Kaoru Abe , Tomonori Nakagawa , Koichi Shinhama , Naoto Utsumi , Michiaki Tominaga , Yoshihiro Ooi , Shohei Yamada , Kenji Tomikawa
- 申请人地址： JP Tokyo
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 优先权： JP2001-290645 20010925; JP2001-348276 20011114; CA2379005 20020327
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D215/227 ; A61K31/497
摘要：
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous Aripiprazole crystals is stored for an extended period.
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