Multi-piece golf balls having a solid core of at least one layer and cover of at least one layer are provided. At least one of the layers is formed from a thermoplastic polyamide composition, consisting essentially of a blend of about 40 to about 99% by weight polyamide and about 1 to about 60% by weight fatty acid salt. Preferably, the ball has a dual core construction. A rubber composition is preferably used to form the inner core and the polyamide composition is preferably used to form the outer core layer. The resulting ball has high resiliency along with a soft feel.