Invention Grant
US08906920B2 N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes 有权
N - ((1R,2S,5R)-5-(叔丁基氨基)-2 - ((S)-3-(7-叔丁基吡唑并[1,5-A] 吡啶-4-基氨基)-2-氧代吡咯烷-1-基)环己基)乙酰胺,趋化因子受体活性的双重调节剂,结晶形式和方法

  • Patent Title: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
  • Patent Title (中): N - ((1R,2S,5R)-5-(叔丁基氨基)-2 - ((S)-3-(7-叔丁基吡唑并[1,5-A] 吡啶-4-基氨基)-2-氧代吡咯烷-1-基)环己基)乙酰胺,趋化因子受体活性的双重调节剂,结晶形式和方法
  • Application No.: US14091388
    Application Date: 2013-11-27
  • Publication No.: US08906920B2
    Publication Date: 2014-12-09
  • Inventor: Percy H. CarterRobert J. Cherney
  • Applicant: Bristol-Myers Squibb Company
  • Applicant Address: US NJ Princeton
  • Assignee: Bristol-Myers Squibb Company
  • Current Assignee: Bristol-Myers Squibb Company
  • Current Assignee Address: US NJ Princeton
  • Agent Elliott Korsen
  • Main IPC: C07D487/04
  • IPC: C07D487/04 A61K31/53 A61P13/12
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
Abstract:
The present invention provides a novel antagonist: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide: or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual CCR-2 and CCR-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed. The present disclosure also provides processes for preparing compounds of Formula (I) as provided herein, including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide. Compounds that are useful intermediates of the process are also provided herein.
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